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Research Letter
June 12, 2019

Survival Outcomes Among Patients With Gastric Adenocarcinoma Who Received Hyperthermic Intraperitoneal Chemotherapy With Cytoreductive Surgery

Author Affiliations
  • 1Division of Surgical Oncology, The Ohio State University Wexner Medical Center, Columbus
JAMA Surg. Published online June 12, 2019. doi:10.1001/jamasurg.2019.1698

Gastric cancer (GC) with peritoneal metastases is associated with a poor prognosis. Median overall survival (OS) is less than 1 year with systemic chemotherapy alone.1 Hyperthermic intraperitoneal chemotherapy (HIPEC) combined with cytoreductive surgery (CRS) has been used for various peritoneal surface malignant tumors, and there has been marked interest in its application to GC because a small randomized clinical trial demonstrated improved OS among patients who underwent CRS-HIPEC compared with CRS alone.2 Although widespread adoption of HIPEC for GC has been limited because of poor oncologic outcomes and high perioperative morbidity,3 interest in the use of intraperitoneal chemotherapy for patients with advanced GC persists.1 We assessed survial outcomes among patients with gastric adenocarcinoma who received CRS-HIPEC at academic centers across the United States.

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