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Comment & Response
August 28, 2019

Ideal Total Joint Arthroplasty Antibiotic Prophylaxis Unknown

Author Affiliations
  • 1Department of Orthopaedic Surgery and Rehabilitation, University of Rochester Medical Center, Rochester, New York
  • 2Division of Adult Reconstruction, Orthopaedic Surgery, University of Rochester Medical Center, Rochester, New York
JAMA Surg. 2019;154(12):1168-1169. doi:10.1001/jamasurg.2019.2902

To the Editor We commend the authors of “Association of Duration and Type of Surgical Prophylaxis With Antimicrobial-Associated Adverse Events” on their investigation efforts into an important topic of discussion.1 They retrospectively reviewed the Veterans Affairs Surgical Quality Improvement Project Database to assess postoperative 30-day surgical site infections (SSIs), 7-day incidence of acute kidney injury (AKI), and development of Clostridium difficile infection at 90 days after cardiac, vascular, colorectal, and orthopedic surgery. They concluded that longer duration of prophylactic antibiotics did not lead to decreased rate of SSI but rather increased rates of AKI and C difficile infection.

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