In this issue of JAMA Surgery, Jones et al1 provide a detailed accounting of recurrence patterns of pancreatic ductal adenocarcinoma (PDAC) following resection. While not the primary aim of the European Study Group for Pancreatic Cancer (ESPAC)–4 randomized clinical trial,2 recurrence of PDAC was analyzed for 732 patients receiving adjuvant gemcitabine alone or gemcitabine plus capecitabine. Although these agents have essentially become obsolete with the adoption of FOLFIRINOX (fluorouracil, leucovorin, oxaliplatin, and irinotecan) for treatment of PDAC, the current study manages to provoke many curiosities.
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Trudeau M, Vollmer CM. Pancreatic Ductal Adenocarcinoma—ESPAC…or It’s Back? JAMA Surg. 2019;154(11):1048. doi:10.1001/jamasurg.2019.3364
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