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Comment & Response
October 9, 2019

Cerebral Autoregulation-Targeted Mean Arterial Pressure

Author Affiliations
  • 1Division of Cardiothoracic Anesthesiology, Department of Anesthesiology, Virginia Commonwealth University, Richmond
  • 2Virginia Commonwealth University, Richmond
JAMA Surg. Published online October 9, 2019. doi:10.1001/jamasurg.2019.3790

To the Editor We read the study by Brown et al1 with great interest. They report a 45% reduction in the odds of delirium in patients undergoing cardiac surgery by a maintaining mean arterial pressure greater than a computationally identified cerebral autoregulatory threshold. These results suggest that relative hypotension could represent an etiology for this common form of acute temporary brain injury. Their results are impressive; however, the effect size seems biologically and clinically implausible. Moreover, delirium is usually regarded as multifactorial, with the existence of patient-related predisposing factors as well as pharmaceutical and behavioral/environmental factors.

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