To the Editor We read the study by Brown et al1 with great interest. They report a 45% reduction in the odds of delirium in patients undergoing cardiac surgery by a maintaining mean arterial pressure greater than a computationally identified cerebral autoregulatory threshold. These results suggest that relative hypotension could represent an etiology for this common form of acute temporary brain injury. Their results are impressive; however, the effect size seems biologically and clinically implausible. Moreover, delirium is usually regarded as multifactorial, with the existence of patient-related predisposing factors as well as pharmaceutical and behavioral/environmental factors.
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Pal N, Worrall E, Butterworth J. Cerebral Autoregulation-Targeted Mean Arterial Pressure. JAMA Surg. 2020;155(1):92–93. doi:10.1001/jamasurg.2019.3790
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