[Skip to Navigation]
Sign In
Views 352
Citations 0
Comment & Response
October 9, 2019

Cerebral Autoregulation-Targeted Mean Arterial Pressure—Reply

Author Affiliations
  • 1Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland
  • 2Bluhm Cardiovascular Institute, Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois
JAMA Surg. 2020;155(1):94. doi:10.1001/jamasurg.2019.3802

In Reply We thank the letter writers for their comments regarding our article, “Effect of Targeting Mean Arterial Pressure During Cardiopulmonary Bypass by Monitoring Cerebral Autoregulation on Postsurgical Delirium Among Older Patients: A Nested Randomized Clinical Trial.”1 We recognize that this is a small single-center study with limitations. The methods used to characterize autoregulation in this particular study can be labor intensive and the data subject to interpretation. There were some differences between groups in perioperative characteristics, including obstructive sleep apnea and temperature management. For all of these reasons and more, we tried to be tempered in our conclusions, in particular stating that “these results should be considered preliminary and need to be confirmed in a broad population.”1

Add or change institution
Limit 200 characters
Limit 25 characters
Conflicts of Interest Disclosure

Identify all potential conflicts of interest that might be relevant to your comment.

Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.

Err on the side of full disclosure.

If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.

Not all submitted comments are published. Please see our commenting policy for details.

Limit 140 characters
Limit 3600 characters or approximately 600 words