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Comment & Response
October 9, 2019

Cerebral Autoregulation-Targeted Mean Arterial Pressure—Reply

Author Affiliations
  • 1Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland
  • 2Bluhm Cardiovascular Institute, Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois
JAMA Surg. Published online October 9, 2019. doi:10.1001/jamasurg.2019.3802

In Reply We thank the letter writers for their comments regarding our article, “Effect of Targeting Mean Arterial Pressure During Cardiopulmonary Bypass by Monitoring Cerebral Autoregulation on Postsurgical Delirium Among Older Patients: A Nested Randomized Clinical Trial.”1 We recognize that this is a small single-center study with limitations. The methods used to characterize autoregulation in this particular study can be labor intensive and the data subject to interpretation. There were some differences between groups in perioperative characteristics, including obstructive sleep apnea and temperature management. For all of these reasons and more, we tried to be tempered in our conclusions, in particular stating that “these results should be considered preliminary and need to be confirmed in a broad population.”1

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