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Comment & Response
December 26, 2019

Prognostic Value of Pancreatic Fistula in Resected Patients With Pancreatic Cancer With Neoadjuvant Therapy

Author Affiliations
  • 1Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia
JAMA Surg. Published online December 26, 2019. doi:10.1001/jamasurg.2019.5090

To the Editor We read with interest the study of Hank et al,1 which proposes that there is a decreased risk of developing clinically relevant pancreatic fistula (CR-POPF) when neoadjuvant chemotherapy (NAT) therapy is applied for pancreatic adenocarcinoma. They suggest induction of fibrosis of the pancreatic gland as a proposed mechanism. While the data appear intriguing, there are some methodologic issues that raise questions.

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