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Invited Commentary
January 22, 2020

End-stage Renal Disease After Kidney Donation—More Research Needed

Author Affiliations
  • 1Division of Transplantation, Department of Surgery, University of Minnesota, Minneapolis
  • 2Division of Renal Diseases and Hypertension, Houston Methodist Hospital, Houston, Texas
  • 3Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis
JAMA Surg. 2020;155(3):e195473. doi:10.1001/jamasurg.2019.5473

Concern about long-term donor outcomes has existed since the first kidney transplant was performed. Studies1,2 comparing long-term outcomes among living donors with those of the general population have found no differences; however, 2 recent studies comparing donors with healthy selected control participants have found that living kidney donors have a small increased risk for end-stage renal disease (ESRD).3,4 These studies have limitations in both choice of control participants and statistical analyses.5

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