Evidence-based medicine in surgery is essential to the delivery of high-quality care. Comparative effectiveness research (CER) using observational study designs refers to the wide scope of research that allows for the generation of evidence to support one care strategy over another. Comparative effectiveness research is defined by the Institute of Medicine as the “generation and synthesis of evidence that compares the benefits and harms of alternative methods to prevent, diagnose, treat, and monitor a clinical condition or to improve the delivery of care.”1 The purpose of CER is to provide actionable evidence to consumers, clinicians, purchasers, and policy makers to make informed decisions.1
Identify all potential conflicts of interest that might be relevant to your comment.
Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.
Err on the side of full disclosure.
If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.
Not all submitted comments are published. Please see our commenting policy for details.
Merkow RP, Schwartz TA, Nathens AB. Practical Guide to Comparative Effectiveness Research Using Observational Data. JAMA Surg. Published online January 29, 2020. doi:10.1001/jamasurg.2019.4395
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: