In this issue of JAMA Surgery, Bailly et al1 report on the association of incident colorectal cancer (CRC) risk with bariatric surgery in a large sample of surgical and nonsurgical patients from the French National Health Insurance Information System. Using multivariable propensity score matching, they report a hazard ratio (HR) of 0.68 (95% CI, 0.60-0.77) for CRC when comparing patients undergoing bariatric surgery with matched nonsurgical patients. When the expected-to-observed CRC rates in the bariatric surgery group and matched nonsurgical patients were compared with the general population, the standardized incidence ratios (SIRs) were 1.0 (95% CI, 0.90-1.09) and 1.34 (95% CI, 1.32-1.36), respectively. The authors concluded that while nonsurgery patients with severe obesity had a 34% greater risk for incident CRC compared with the general population, patients undergoing bariatric surgery had an incident risk the same as the general population and a 32% lower incident CRC compared with matched nonsurgical patients.
Identify all potential conflicts of interest that might be relevant to your comment.
Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.
Err on the side of full disclosure.
If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.
Not all submitted comments are published. Please see our commenting policy for details.
Davidson LE, Adams TD. Does Bariatric Surgery Increase or Reduce Colorectal Cancer Risk—Is the Jury Still Out? JAMA Surg. Published online March 11, 2020. doi:10.1001/jamasurg.2020.0090
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: