Gastrointestinal stromal tumors (GISTs) are malignant tumors arising from interstitial cells of cajal that can be located in any part of the digestive system.1 Their most common sites are the stomach and small intestine.2 Surgery either upfront or after preoperative treatment with tyrosine kinase inhibitors (TKIs) is still the most important treatment modality in GIST.2 In this issue of JAMA Surgery, Gronchi et al3 evaluate the association of microscopic radicality with patient outcomes. They use long-term data from a randomized clinical trial in which patients received TKI for 2 years or no adjuvant treatment after surgery to examine the association of R1 resection (no free margins) with recurrence and survival.
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Almquist M, Nordenström E. R1 Resection in Gastrointestinal Stromal Tumors Is Not Worse Than R0. JAMA Surg. Published online April 01, 2020. doi:10.1001/jamasurg.2020.0398
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