Sex-based disparities in solid organ transplant exist in every studied phase of the endeavor, from patient access to outcomes1 to the physicians performing the operations.2 In this issue of JAMA Surgery, Locke et al3 present a retrospective analysis of the United Network for Organ Sharing database that confirms previously published sex-based disparities in liver transplant while adding a shrewd analysis of the components that lead to these disparities. Distressingly (although not surprisingly), they found that women were more likely than men (by 9%) to die on the liver transplant waiting list and less likely (by 14%) to receive a deceased-donor liver transplant. Careful analysis of component contribution to these numbers revealed that Model for End-stage Liver Disease (MELD) factors (eg, creatinine) and candidate body size played large parts in the noted sex inequalities, while geographic factors played a far smaller role. Based on these findings, the authors suggest a more comprehensive approach to fixing inequalities in organ allocation than one simply based on geographical concerns.
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Naugler WE, Orloff SL. Sex Does Matter in Liver Allocation—Time to Address Existing Sex-Based Disparities. JAMA Surg. 2020;155(7):e201130. doi:10.1001/jamasurg.2020.1130
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