To the Editor In the February 2020 issue of JAMA Surgery, Pusateri et al1 reported that prehospital plasma transfusion is associated with survival benefit when transport times are longer than 20 minutes and, more generally, that benefit-risk ratio is favorable for use of prehospital plasma. First, the authors must be congratulated for this impressive secondary post hoc analysis merging 2 randomized clinical trials with contrary results, COMBAT and PAMPer.