In this issue of JAMA Surgery, Newton et al1 present findings from a retrospective analysis of MarketScan Commercial Database health insurance claims data that documents that fluoroquinolone use vs comparator antibiotics is associated with an increased incidence of aortic aneurysm (AA) formation within 90 days in a large cohort of US adults. Mechanistically, this association is primarily for abdominal aortic and iliac artery aneurysms, not aortic dissections (ADs) or thoracic aortic aneurysms. The association was present across all age groups (≥35 to <65 years) and was consistent across sex and comorbidities. The study also documents that adult patients were more likely to undergo aneurysm repair (hazard ratio, 1.88; 95% CI, 1.44-2.46).
Identify all potential conflicts of interest that might be relevant to your comment.
Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.
Err on the side of full disclosure.
If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.
Not all submitted comments are published. Please see our commenting policy for details.
Filiberto AC, Upchurch GR. Fluoroquinolones and Aortic Disease—Is It Time to Broaden the Warning? JAMA Surg. 2021;156(3):273. doi:10.1001/jamasurg.2020.6185
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.