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Original Investigation
January 20, 2021

Risk of Hematologic Malignant Neoplasms From Abdominopelvic Computed Tomographic Radiation in Patients Who Underwent Appendectomy

Author Affiliations
  • 1Department of Radiology, Seoul National University Bundang Hospital, Gyeonggi-do, Korea
  • 2Department of Radiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Gyeonggi-do, Korea
  • 3Department of Applied Bioengineering, Seoul National University Graduate School of Convergence Science and Technology, Seoul, Korea
  • 4Department of Preventive Medicine, Korea University College of Medicine, Seoul, Korea
  • 5Department of Nuclear Engineering, Kyung Hee University, Gyeonggi-do, Korea
  • 6Department of Public Health Science, Seoul National University Graduate School of Public Health, Seoul, Korea
  • 7Division of Hematology-Oncology, Department of Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, Korea
  • 8Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, Korea
JAMA Surg. 2021;156(4):343-351. doi:10.1001/jamasurg.2020.6357
Key Points

Question  Is there a risk of hematologic malignant neoplasms from abdominopelvic computed tomography (CT) radiation when reverse causation bias is controlled for by defining the reasons for CT scan?

Findings  In this nationwide population-based cohort study that included 825 820 patients who underwent appendectomy for acute appendicitis, there was a substantial excess risk of hematologic malignant neoplasms in the CT-exposed group compared with the CT-unexposed group. The carcinogenic risk was most pronounced in patients aged 0 to 15 years.

Meaning  In this study, perioperative abdominopelvic CT was associated with a higher incidence of hematologic malignant neoplasms.

Abstract

Importance  Whether computed tomography (CT) radiation is truly carcinogenic remains controversial. Large epidemiological studies that purportedly showed an association between CT radiation and carcinogenesis were limited by confounding by indication and reverse causation, because the reasons for CT examination were unknown.

Objective  To measure the risk of hematologic malignant neoplasms associated with perioperative abdominopelvic CT radiation among patients who underwent appendectomy for acute appendicitis.

Design, Setting, and Participants  This nationwide population-based cohort study used the National Health Insurance Service claims database in South Korea to assess 825 820 patients who underwent appendectomy for appendicitis from January 1, 2005, to December 31, 2015, and had no underlying risk factors for cancer. Patients were divided into CT-exposed (n = 306 727) or CT-unexposed (n = 519 093) groups. The study was terminated on December 31, 2017, and data were analyzed from October 30, 2018, to September 27, 2020.

Exposures  Perioperative abdominopelvic CT examination from 7 days before to 7 days after appendectomy.

Main Outcomes and Measures  The primary outcome was the incidence rate ratio (IRR) of hematologic malignant neoplasms for both groups. The secondary outcomes were IRR of abdominopelvic organ cancers and IRR of all cancers. The lag period was 2 years for the primary outcome and 5 years for secondary outcomes. The IRRs were calculated using Poisson regression models with adjustment for age and sex.

Results  Among the study population of 825 820 patients (52.9% male; median age, 28 [interquartile range, 15-41] years), hematologic malignant neoplasms developed in 323 patients in the CT-exposed group during 1 486 518 person-years and 500 patients in the CT-unexposed group during 3 422 059 person-years. For all hematologic malignant neoplasms, the IRR for the CT-exposed vs CT-unexposed group was 1.26 (95% CI, 1.09-1.45; P = .002). In terms of individual categories of hematologic malignant neoplasms, the CT-exposed group had an elevated risk only for leukemia (IRR, 1.40 [98.75% CI, 1.04-1.87, adjusted by Bonferroni correction]; P = .005). There was no between-group difference in incidence rate of abdominopelvic organ cancers (IRR, 1.07 [95% CI, 1.00-1.15]; P = .06) and that of all cancers (IRR, 1.04 [95% CI, 0.99-1.09]; P = .14).

Conclusions and Relevance  This study controlled for reverse causation bias by defining the reasons for CT scan, and findings suggest that abdominopelvic CT radiation is associated with a higher incidence of hematologic malignant neoplasms. Efforts should be continued for judicious use of CT examinations.

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    1 Comment for this article
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    Radiosensitive Red Marrow. Where is the Evidence?
    Bhavin Jankharia, MD | Picture This
    We are worried about one of the statements made by the authors. “Because red bone marrow is among the most radiosensitive tissues, the carcinogenic risk of hematologic malignant neoplasms from ionizing radiation has been of particular concern.”

    There are four references [2-5] quoted by them to support this argument, the first two [2,3] in the Introduction and the next two [4,5] in Outcomes. All four are similar longitudinal studies and the only proof they all offer is a set of documents by UNSCEAR [6,7] that describe doses to the red marrow. None of the documents explicitly states that red
    marrow is more sensitive as far as stochastic effects are concerned, nor is there any evidence offered from any basic sciences studies to show that there is increased DNA damage to red marrow from low dose medical imaging radiation.

    If such proof does not exist, then the rest of the arguments don’t work. Isn’t it therefore possible that the excess 66 cases of malignancy are a statistical aberration rather than the result of radiation, even though reverse causation has been accounted for in this particular study?

    It would be nice if the authors could provide the justification/references/citations for the “radiosensitive red marrow” statement/theory.
    CONFLICT OF INTEREST: None Reported
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