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Comment & Response
March 24, 2021

Association of Sarcopenia and Body Composition With Postoperative 90-Day Morbidity After Liver Resection for Malignant Tumors—Reply

Author Affiliations
  • 1Department of General Surgery and Liver Transplantation, San Camillo Forlanini Hospital, Rome, Italy
JAMA Surg. 2021;156(6):590-591. doi:10.1001/jamasurg.2021.0234

In Reply We would like to thank Diao et al for their interest in our work1 and for their questions. They certainly raised some good points that need further clarification. To answer the first comment, our sample size was calculated on the difference between the sarcopenic and the nonsarcopenic group. Sarcopenia was defined by muscle mass and muscle strength as discussed in our study.1 Once we achieved the sample size and ran the statistical analysis, we decided to further break down the results to see if any further message could be retrieved from our study. That is why results are presented in 4 groups in the article; despite differences among the original groups presented, we must admit that Diao et al are right that the subgroup analysis was not specified a priori, and this might limit the interpretation. However, we strongly believe that the final message of sarcopenia as a predictor of morbidity after liver surgery for malignant neoplasm is well supported by our sample size.

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