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Comment & Response
July 7, 2021

Concerns About Study on Fluoroquinolone Use and Risk of Development Of Aortic Aneurysm–Reply

Author Affiliations
  • 1Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill
  • 2Division of Intramural Research, National Institute on Minority Health and Health Disparities, National Institutes of Health, Bethesda, Maryland
  • 3Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill
  • 4Editor, JAMA Surgery
JAMA Surg. 2021;156(11):1069-1070. doi:10.1001/jamasurg.2021.3029

In Reply We thank Chen et al and Sterpetti for their thoughtful comments on our study1 and appreciate the opportunity to clarify our work. Chen et al expressed concerns regarding the broad-spectrum nature of ciprofloxacin and levofloxacin; this is an excellent point. While we did include augmentin as another broad-spectrum comparator, it is important to note that our study was limited to outpatient oral antibiotic prescription fills. We excluded individuals who were hospitalized within 30 days of their prescription fill, thereby minimizing the probability of including those with severe clinical illness in the analysis.

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