In Reply Mraovic et al disagree with the recommendation to administer cefazolin for prophylaxis of surgical site infections to patients with a history of penicillin allergy, asserting that the risk of severe anaphylaxis is too great. This recommendation is based on the difference in frequency of dual cefazolin-penicillin allergy between patients with confirmed penicillin allergy (3.0%) and patients with unconfirmed penicillin allergy (0.6%).1 We acknowledge the risk of hypersensitivity to cefazolin is indeed greater for patients with confirmed penicillin allergies, but we suggest this greater risk may not be entirely specific to cefazolin but to the patient population with drug allergies.
Identify all potential conflicts of interest that might be relevant to your comment.
Conflicts of interest comprise financial interests, activities, and relationships within the past 3 years including but not limited to employment, affiliation, grants or funding, consultancies, honoraria or payment, speaker's bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued.
Err on the side of full disclosure.
If you have no conflicts of interest, check "No potential conflicts of interest" in the box below. The information will be posted with your response.
Not all submitted comments are published. Please see our commenting policy for details.
Jeffres MN, Sousa-Pinto B, Blumenthal KG. Dual Allergy to Penicillin and Cefazolin—Does Anaphylaxis Matter?—Reply. JAMA Surg. 2021;156(12):1184–1185. doi:10.1001/jamasurg.2021.3761
Monkeypox Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.