To the Editor We read with great interest the study by Chesney et al.1 In this population-based cohort study using 8 health administrative databases in Ontario, Canada, among 82 037 older adults undergoing cancer surgery, 6443 (7.9%) had preoperative frailty and 55 491 (67.6%) experienced perioperative (preoperative and/or postoperative) chemotherapy or radiotherapy within 180 days before or after surgery. Of note, the results of this study identified that preoperative frailty was independently associated with cancer and noncancer deaths, while perioperative therapy was independently associated with noncancer death of older adults after cancer surgery. Despite this inspiring and thought-provoking study, we have the following comments.
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Sun L, Zhu J, Yang T. Associations of Preoperative Frailty With Cancer and Noncancer Deaths of Older Adults Following Surgery for Cancer. JAMA Surg. 2022;157(1):82–83. doi:10.1001/jamasurg.2021.4408
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