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Comment & Response
September 8, 2021

Associations of Preoperative Frailty With Cancer and Noncancer Deaths of Older Adults Following Surgery for Cancer

Author Affiliations
  • 1Department of Hepatobiliary, Pancreatic and Minimal Invasive Surgery, Zhejiang Provincial People’s Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China
  • 2Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University (Navy Medical University), Shanghai, China
JAMA Surg. 2022;157(1):82-83. doi:10.1001/jamasurg.2021.4408

To the Editor We read with great interest the study by Chesney et al.1 In this population-based cohort study using 8 health administrative databases in Ontario, Canada, among 82 037 older adults undergoing cancer surgery, 6443 (7.9%) had preoperative frailty and 55 491 (67.6%) experienced perioperative (preoperative and/or postoperative) chemotherapy or radiotherapy within 180 days before or after surgery. Of note, the results of this study identified that preoperative frailty was independently associated with cancer and noncancer deaths, while perioperative therapy was independently associated with noncancer death of older adults after cancer surgery. Despite this inspiring and thought-provoking study, we have the following comments.

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