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Invited Commentary
September 29, 2021

The Evolution of Multimodality Treatment of Rectal Cancer

Author Affiliations
  • 1Department of Surgery, The Johns Hopkins Hospital, Baltimore, Maryland
  • 2Division of Colon and Rectal Surgery, Department of Surgery, The Johns Hopkins Hospital, Baltimore, Maryland
  • 3Department of Oncology, The Johns Hopkins Hospital, Baltimore, Maryland
JAMA Surg. 2021;156(12):1149-1150. doi:10.1001/jamasurg.2021.4567

At the turn of the century, prospective randomized clinical trials supported the use of neoadjuvant chemoradiation therapy (nCRT) prior to total mesorectal excision (TME) of locally advanced rectal cancers (LARC).1,2 Few studies have determined the optimal time interval between nCRT and surgery, which is traditionally 6 to 12 weeks with the fundamental intent that extending the time interval to TME achieves further tumor regression or a pathologic complete response.

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