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Comment & Response
October 20, 2021

Generalizability of the Results and Concerns About Leakage Rates of the ICAN Trial

Author Affiliations
  • 1Surgical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India
JAMA Surg. 2022;157(2):175-176. doi:10.1001/jamasurg.2021.5260

To the Editor The ICAN trial has provided level 1 evidence favoring intrathoracic anastomosis after a total or hybrid minimally invasive esophagectomy.1 We commend the authors on a robust study design for a purely surgical trial. The quality control of the surgical technique before participation and later during the trial is meticulous and may lay the standard for future surgical trials.

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