Rosenberg and colleagues1 first proposed the use of nonabsorbable oral antibiotic preparation (OAB) for colorectal surgery in 1971. In a randomized clinical trial, they demonstrated a reduction in surgical site infection and anastomotic leak rates after combined mechanical bowel preparation (MBP) and 1 or 2 nonabsorbable oral antibiotics (phthalylsulphathiazole and phthalylsulphathiazole and neomycin, respectively) compared with MBP alone.
Ljungqvist O, Lobo DN. Bowel Preparation for Colorectal Surgery: Have All Questions Been Answered? JAMA Surg. 2022;157(1):41–42. doi:10.1001/jamasurg.2021.5273
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