To the Editor We read with great interest the results from the study by de Boniface et al,1 which indicated a significantly higher comorbidity burden in patients using mastectomy irrespective of postoperative radiotherapy, compared with those treated with breast-conserving surgery with radiotherapy in patients with early-stage breast cancer. Moreover, after stepwise adjustment for all covariates, overall survival and breast cancer–specific survival were significantly worse after mastectomy without radiotherapy and mastectomy with radiotherapy than after breast-conserving surgery plus radiotherapy. Based on these results, the authors stated that mastectomy should not be regarded as equal to breast conservation.
Lin X, Chen W, Wei F. Eradication of Potential In-Transit Metastasis in Breast-Conserving Surgery. JAMA Surg. 2022;157(2):174. doi:10.1001/jamasurg.2021.5349
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