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Comment & Response
October 27, 2021

Eradication of Potential In-Transit Metastasis in Breast-Conserving Surgery

Author Affiliations
  • 1Department of Breast Surgery, Fujian Provincial Maternity and Children’s Hospital of Fujian Medical University, Fuzhou, China
  • 2Department of Physiology, Zhongshan Medical School, Sun Yat-sen University, Guangzhou, China
  • 3Department of Emergency, Fujian Provincial 2nd People’s Hospital, Affiliated Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, China
JAMA Surg. 2022;157(2):174. doi:10.1001/jamasurg.2021.5349

To the Editor We read with great interest the results from the study by de Boniface et al,1 which indicated a significantly higher comorbidity burden in patients using mastectomy irrespective of postoperative radiotherapy, compared with those treated with breast-conserving surgery with radiotherapy in patients with early-stage breast cancer. Moreover, after stepwise adjustment for all covariates, overall survival and breast cancer–specific survival were significantly worse after mastectomy without radiotherapy and mastectomy with radiotherapy than after breast-conserving surgery plus radiotherapy. Based on these results, the authors stated that mastectomy should not be regarded as equal to breast conservation.

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