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Comment & Response
January 5, 2022

Liver Transplant for Alcohol-Associated Liver Disease

Author Affiliations
  • 1Department of Liver Surgery, Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China
JAMA Surg. 2022;157(4):360. doi:10.1001/jamasurg.2021.6550

To the Editor Alcohol-associated liver disease depicts a clinical-histologic spectrum of steatosis, alcoholic hepatitis, and alcoholic cirrhosis (AC).1 A recent guideline posts that decompensated patients with AC should be considered for liver transplant (LT) irrespective of 6-month abstinence.1 While AC has become the leading indication for LT and prognosis favors patients with AC over other etiologies of cirrhosis, early LT (without the 6-month waiting period) for severe alcoholic hepatitis (SAH) remains a debate.1 In JAMA Surgery, the study by Herrick-Reynolds et al2 revealed that fulfillment of fixed abstinence did not improve post-LT outcomes of patients with alcohol-associated liver disease. Presence of 95.7% AC (vs 49.1% for SAH) supported by explant pathology partially explains the failure of the 6-month sobriety for outcome improvement. Therefore, results concerning the individuals with SAH would be more intriguing.

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