To the Editor Deidda et al1 address the question in their recent article: does delaying surgery beyond 8 weeks in patients with rectal cancer who respond poorly to chemoradiation lead to worsening of oncological outcomes? After exclusion of those who respond well (patients with pathological complete response or downstaged to ypT1N0), they showed that extending interval to surgery beyond 8 weeks after completing chemoradiation was associated with significantly worse oncological outcomes. The authors concluded that patients who do not respond well to chemoradiation should be identified early and undergo surgery without delay.
Socha J, Bujko K. Comment on Timing of Surgery For Patients With Rectal Cancers Not Responding to Preoperative Chemoradiation. JAMA Surg. 2022;157(6):549–550. doi:10.1001/jamasurg.2021.7591
Artificial Intelligence Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.