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Comment & Response
February 23, 2022

Comment on Timing of Surgery For Patients With Rectal Cancers Not Responding to Preoperative Chemoradiation

Author Affiliations
  • 1Department of Radiotherapy, Military Institute of Medicine, Warsaw, Poland
  • 2Department of Radiotherapy I, Maria Skłodowska-Curie National Research Institute of Oncology, Warsaw, Poland
JAMA Surg. 2022;157(6):549-550. doi:10.1001/jamasurg.2021.7591

To the Editor Deidda et al1 address the question in their recent article: does delaying surgery beyond 8 weeks in patients with rectal cancer who respond poorly to chemoradiation lead to worsening of oncological outcomes? After exclusion of those who respond well (patients with pathological complete response or downstaged to ypT1N0), they showed that extending interval to surgery beyond 8 weeks after completing chemoradiation was associated with significantly worse oncological outcomes. The authors concluded that patients who do not respond well to chemoradiation should be identified early and undergo surgery without delay.

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