Comment on Timing of Surgery For Patients With Rectal Cancers Not Responding to Preoperative Chemoradiation

Joanna Socha; Krzysztof Bujko

doi:10.1001/jamasurg.2021.7591

Comment & Response

February 23, 2022

Comment on Timing of Surgery For Patients With Rectal Cancers Not Responding to Preoperative Chemoradiation

Joanna Socha, MD, PhD¹; Krzysztof Bujko, MD, PhD²

Author Affiliations Article Information

¹Department of Radiotherapy, Military Institute of Medicine, Warsaw, Poland
²Department of Radiotherapy I, Maria Skłodowska-Curie National Research Institute of Oncology, Warsaw, Poland

JAMA Surg. 2022;157(6):549-550. doi:10.1001/jamasurg.2021.7591

Original Investigation

Delayed Surgery and Long-term Outcomes in Patients With Nonresponsive Locally Advanced Rectal Cancer

Simona Deidda, MD; Ugo Elmore, MD; Riccardo Rosati, MD; Paola De Nardi, MD; Andrea Vignali, MD; Francesco Puccetti, MD; Gaya Spolverato, MD; Giulia Capelli, MD; Matteo Zuin, MD; Andrea Muratore, MD; Riccardo Danna, MD; Marcello Calabrò, MD; Mario Guerrieri, MD; Monica Ortenzi, MD; Roberto Ghiselli, MD; Stefano Scabini, MD; Alessandra Aprile, MD; Davide Pertile, MD; Giuseppe Sammarco, MD; Gaetano Gallo, MD; Giuseppe Sena, MD; Claudio Coco, MD; Gianluca Rizzo, MD; Donato Paolo Pafundi, MD; Claudio Belluco, MD; Roberto Innocente, MD; Maurizio Degiuli, MD; Rossella Reddavid, MD; Lucia Puca, MD; Paolo Delrio, MD; Daniela Rega, MD; Pietro Conti, MD; Alessandro Pastorino, MD; Luigi Zorcolo, MD; Salvatore Pucciarelli, MD; Carlo Aschele, MD; Angelo Restivo, MD

JAMA Surgery
Comment & Response

Comment on Timing of Surgery For Patients With Rectal Cancers Not Responding to Preoperative Chemoradiation—Reply

Simona Deidda, MD; Gaya Spolverato, MD; Angelo Restivo, MD

JAMA Surgery
Comment & Response

Comment on Timing of Surgery For Patients With Rectal Cancers Not Responding to Preoperative Chemoradiation

Catherine Dunn, MBBS; Lucy Gately, MBBS, PhD; Peter Gibbs, MBBS, MD

JAMA Surgery
Comment & Response

Comment on Timing of Surgery For Patients With Rectal Cancers Not Responding to Preoperative Chemoradiation

Prudvi Raj, MCh; Swapnil Patel, MCh; Amar Prem, MCh

JAMA Surgery

Full Text

To the Editor Deidda et al¹ address the question in their recent article: does delaying surgery beyond 8 weeks in patients with rectal cancer who respond poorly to chemoradiation lead to worsening of oncological outcomes? After exclusion of those who respond well (patients with pathological complete response or downstaged to ypT1N0), they showed that extending interval to surgery beyond 8 weeks after completing chemoradiation was associated with significantly worse oncological outcomes. The authors concluded that patients who do not respond well to chemoradiation should be identified early and undergo surgery without delay.

Full Text

Comment on Timing of Surgery For Patients With Rectal Cancers Not Responding to Preoperative Chemoradiation

Others Also Liked

Featured Articles

USPSTF Recommendation Statements

Blogs

Comment on Timing of Surgery For Patients With Rectal Cancers Not Responding to Preoperative Chemoradiation

Citation

Download citation file:

Others Also Liked

Select Your Interests