Comment on Timing of Surgery For Patients With Rectal Cancers Not Responding to Preoperative Chemoradiation

Catherine Dunn; Lucy Gately; Peter Gibbs

doi:10.1001/jamasurg.2021.7590

Comment & Response

February 23, 2022

Comment on Timing of Surgery For Patients With Rectal Cancers Not Responding to Preoperative Chemoradiation

Catherine Dunn, MBBS¹; Lucy Gately, MBBS, PhD¹; Peter Gibbs, MBBS, MD^1,2

Author Affiliations Article Information

¹Personalised Medicine Division, Walter and Eliza Hall Research Institute, Melbourne, Victoria, Australia
²Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia

JAMA Surg. 2022;157(6):548-549. doi:10.1001/jamasurg.2021.7590

Original Investigation

Delayed Surgery and Long-term Outcomes in Patients With Nonresponsive Locally Advanced Rectal Cancer

Simona Deidda, MD; Ugo Elmore, MD; Riccardo Rosati, MD; Paola De Nardi, MD; Andrea Vignali, MD; Francesco Puccetti, MD; Gaya Spolverato, MD; Giulia Capelli, MD; Matteo Zuin, MD; Andrea Muratore, MD; Riccardo Danna, MD; Marcello Calabrò, MD; Mario Guerrieri, MD; Monica Ortenzi, MD; Roberto Ghiselli, MD; Stefano Scabini, MD; Alessandra Aprile, MD; Davide Pertile, MD; Giuseppe Sammarco, MD; Gaetano Gallo, MD; Giuseppe Sena, MD; Claudio Coco, MD; Gianluca Rizzo, MD; Donato Paolo Pafundi, MD; Claudio Belluco, MD; Roberto Innocente, MD; Maurizio Degiuli, MD; Rossella Reddavid, MD; Lucia Puca, MD; Paolo Delrio, MD; Daniela Rega, MD; Pietro Conti, MD; Alessandro Pastorino, MD; Luigi Zorcolo, MD; Salvatore Pucciarelli, MD; Carlo Aschele, MD; Angelo Restivo, MD

JAMA Surgery
Comment & Response

Comment on Timing of Surgery For Patients With Rectal Cancers Not Responding to Preoperative Chemoradiation—Reply

Simona Deidda, MD; Gaya Spolverato, MD; Angelo Restivo, MD

JAMA Surgery
Comment & Response

Comment on Timing of Surgery For Patients With Rectal Cancers Not Responding to Preoperative Chemoradiation

Joanna Socha, MD, PhD; Krzysztof Bujko, MD, PhD

JAMA Surgery
Comment & Response

Comment on Timing of Surgery For Patients With Rectal Cancers Not Responding to Preoperative Chemoradiation

Prudvi Raj, MCh; Swapnil Patel, MCh; Amar Prem, MCh

JAMA Surgery

Full Text

To the Editor The optimal timing of surgery following chemoradiotherapy for rectal cancer continues to be debated. Adding to the literature is a recent analysis of Italian registry data,¹ finding that surgery beyond 8 weeks in patients with a poor response was associated with worse survival outcomes. Based on this finding, the authors recommend patients who do not respond well to chemoradiotherapy (ypT3-4 or N1-2) should “be identified early…and undergo surgery without delay.”¹ We are concerned that this strong recommendation was drawn from a single uncontrolled data series. Further, this approach is practically limited by the timing and accuracy of standard chemoradiation response assessment.

Full Text

Comment on Timing of Surgery For Patients With Rectal Cancers Not Responding to Preoperative Chemoradiation

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