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Invited Commentary
June 22, 2022

A Personalized Approach to Prevention of Venous Thromboembolism: One Size Does Not Fit All

Author Affiliations
  • 1Division of Vascular and Endovascular Surgery, Massachusetts General Hospital, Harvard Medical School, Boston
  • 2Department of Surgery, Division of Vascular Surgery, Stanford University School of Medicine, Stanford, California
  • 3Surgical Service Line, Veterans Affairs Palo Alto Healthcare System, Palo Alto, California
JAMA Surg. 2022;157(8):722. doi:10.1001/jamasurg.2022.2204

We read with great interest the article by Vincent et al.1 We commend the authors for their innovative methodology with longitudinal approach to demonstrate acquired antithrombin deficiency in injury and poor responsiveness to enoxaparin and its association with venous thromboembolism (VTE). This article1 adds to recent literature that recognizes key pitfalls in a universal approach to prevention of trauma-related VTE in contrast to a personalized approach to identify anticoagulant resistance and/or nonresponsiveness to optimize therapy.2,3

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