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Invited Commentary
July 6, 2022

Uterine Transplant—Progress, but Concerns Remain

Author Affiliations
  • 1Section of Surgical Sciences, Vanderbilt University Medical Center, Nashville, Tennessee
JAMA Surg. 2022;157(9):797-798. doi:10.1001/jamasurg.2022.2652

The first live birth following successful uterine transplant occurred in Sweden in 2014, marking the beginning of a new era for this life-generating transplant for those with absolute uterine factor infertility.1 Johannesson et al2 present 5-year data from the US Uterus Transplant Consortium. According to the registration file, the primary end points for trials NCT02656550 and NCT02573415 were live births and full-term births. Of 33 participants, 19 (58%) reached a live birth. Although not explicitly stated in the article, according to Figure 4,2 no birth reached full term (39 weeks). Recipients had an 83% chance for a live birth if the graft survived 1 year, corresponding to a recently published worldwide experience of 80% chance of live birth after uterine transplant.3

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