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Invited Critique
November 2000

The Potential Pattern of Circulating Lymphocytes TH1/TH2 Is Not Altered After Multiple Injuries—Invited Critique

Arch Surg. 2000;135(11):1314. doi:10.1001/archsurg.135.11.1314

Dr Wick and colleagues add welcome data to ongoing evaluations of the immunologic effects of severe injury. Using a refined flow cytometric analysis, these investigators further define the effects of blunt trauma on the pattern and function of circulating lymphocytes: TH1 vs TH2 CD3+ cells. Prior studies have produced extremely variable results in the shift from TH1 to TH2 phenotype consistent with an increased risk for infectious and other immunologic complications.

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