The design of a totally implantable hepatic artery infusion pump in 1969 made the use of hepatic artery infusion feasible and practical as a treatment for patients with hepatic neoplasms. The implantable pumps could function for long periods and reliably infuse a measured quantity of drug into the hepatic artery in a continuous fashion. This enabled oncologists to give much higher doses of chemotherapy directly into the blood supply of the tumors as well as to use a continuous infusion schedule.
Kemeny MM. The Surgical Aspects of the Totally Implantable Hepatic Artery Infusion Pump. Arch Surg. 2001;136(3):348–352. doi:10.1001/archsurg.136.3.348
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