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Invited Critique
February 1, 2006

Novel Parathyroid Hormone (1-84) Assay as Basis for Parathyroid Hormone Monitoring in Renal Hyperparathyroidism—Invited Critique

Arch Surg. 2006;141(2):134. doi:10.1001/archsurg.141.2.134

Intraoperative PTH testing has revolutionized the way we treat patients with primary hyperparathyroidism (HPT) by allowing focused, “minimally invasive” procedures targeting resection of a single parathyroid adenoma.1 As shown by Irvin et al, Udelsman et al, our group, and others, intraoperative PTH testing (with first-generation assays) allows detection and subsequent resection of additional hyperfunctioning parathyroid glands intraoperatively, thereby improving cure rates following parathyroidectomy.2-5 Although the importance of intraoperative PTH testing in patients with primary HPT has been defined, its role in patients with secondary HPT is unclear.

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