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Invited Critique
July 1, 2006

Effects of Decreased Preoperative Endotoxin Core Antibody Levels on Long-term Mortality After Coronary Artery Bypass Graft Surgery—Invited Critique

Arch Surg. 2006;141(7):642. doi:10.1001/archsurg.141.7.642

Moretti and colleagues from Duke University have demonstrated that preoperative levels of EndoCAb are associated with increased long-term mortality after CABG surgery using CPB. This is truly a unique finding and worthy of further discussion. Essentially, this finding implies that increased EndoCAb levels carry increased short- and long-term risks after CABG surgery. Although the findings are statistically significant, I’m not sure I understand the logic of this finding. We don't know why the patients died in either subgroup, so it is difficult to explain the increased long-term mortality based on potential increases in EndoCAb levels. In addition, it does not seem that the authors have excluded 30- or 60-day mortality from the analysis.

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