Rios et al1 identified a statistically significant association between the HLA-Cw4 allele and multinodular goiters (15.5% vs 8.3%; P = .001; relative risk = 0.49). This finding was based on a comparison of 90 surgical patients with multinodular goiters from a single institution with a control group of 100 unrelated, healthy blood donors “representative of the healthy population.”
Machens A, Dralle H. Associations of HLA-C Alleles With Multinodular Goiters. Arch Surg. 2006;141(10):1048. doi:10.1001/archsurg.141.10.1048-a
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