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April 20, 2009

Completion Pancreatectomy for Treatment of a Clostridium perfringens Pancreatic Infection

Author Affiliations

Author Affiliations:Departments of Surgery (Drs Cherenfant, Nikfarjam, Kimchi, and Staveley-O[[rsquo]]Carroll) and Gastroenterology (Dr Mathew), Penn State Milton S. Hershey Medical Center, Hershey, Pennsylvania.



Arch Surg. 2009;144(4):368-370. doi:10.1001/archsurg.2009.17

Pancreatic infection is associated with high morbidity and mortality. Drainage of the infection is the usual therapeutic approach. Clostridium perfringensinfection can cause fulminant sepsis, but it rarely occurs within the pancreas. The case of a 76-year-old man with cystic pancreatic lesions in which sepsis developed after endoscopic ultrasound with fine-needle aspiration biopsy is described. The sepsis was managed with pancreatic resection and antibiotics. Clostridium perfringenswas isolated from blood cultures and microbiologic smears from the pancreas. Invasive intraductal papillary mucinous neoplasm with lymph node involvement was identified on histologic examination. The patient made a complete recovery from surgery without complications.

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