We read with great interest the article by Misteli and colleagues1 about the increased risk of surgical site infection (SSI) when surgical glove perforation occurs. Correlation between SSI and glove perforation was explored in 4147 procedures. The incidence of SSI was significantly higher in procedures with glove perforation and no antimicrobial prophylaxis (7.5%) than in procedures without glove perforation (3.9%). The authors concluded that glove perforation should be considered a risk factor for SSI in the absence of surgical antimicrobial prophylaxis, and therefore the latter should be extended to all clean procedures when glove perforations are not prevented by double gloving or glove changing.