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Invited Critique
December 1, 2005

Association of Manganese Superoxide Dismutase Expression With Progression of Carcinogenesis in Barrett Esophagus—Invited Critique

Arch Surg. 2005;140(12):1209. doi:10.1001/archsurg.140.12.1209

Gastroesophageal reflux disease appears to cause cancer through an inflammatory pathway driven by oxygen free radicals.1 We have recently found extensive oxidative DNA damage in an experimental animal model of gastroesophageal reflux disease–induced esophageal cancer.2 It is reasonable to think that SOD could modulate the degree of inflammation and would be important in this type of carcinogenesis.