The extensive clinical and experimental study of the results of transplantation in the same individual of free pieces of bone has led to a clear understanding of the successive steps in the ultimate success or failure of such transplants. The experiments of Phemister,1 Haas, 2 Axhausen, 3 Thalhimer, 4 Brooks 5 and others leave no doubt that the free bone transplant is a source of regeneration of bone and does not act merely as trellis into which bone grows from neighboring sources. These investigators have further shown that the regenerating elements of the bone transplant are the inner layer of the periosteum and the endosteum lining the marrow cavity and the Haversian canals, and that the bone cells in the lacunae take no part in the regeneration of bone. This knowledge places the free autogenous bone transplant on a firm basis as a means of clinical repair of bone
BROOKS B, HUDSON WA. STUDIES IN BONE TRANSPLANTATIONS: AN EXPERIMENTAL STUDY OF THE COMPARATIVE SUCCESS OF AUTOGENOUS AND HOMOGENOUS TRANPLANTS OF BONE IN DOGS. Arch Surg. 1920;1(2):284–309. doi:10.1001/archsurg.1920.01110020077002
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: