In this series of investigations on the bone marrow I have had a two-fold purpose: first, to devise a new method of studying marrow that would secure a connected picture of changes in the marrow, and second, to observe the function of the marrow after the removal of the spleen. The need of this investigation was suggested to me by my findings in a previous study1 of the blood changes after removal of the spleen for kala-azar.Hitherto most observations on the function of the marrow have been limited to single isolated specimens, usually secured at necropsy or by etherizing laboratory animals. A single specimen of bone marrow gives insufficient evidence. An adequate conception of the behavior of the marrow can be secured only by frequent observations (on the same person or laboratory animal) at regular intervals and over a period sufficiently long to afford a connected record
JOHNSTONE EM. CHANGES IN THE MORPHOLOGY AND FUNCTION OF THE BONE MARROW AFTER SPLENECTOMY. Arch Surg. 1922;5(1):159–187. doi:10.1001/archsurg.1922.01110130168006
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.