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August 1925

OSTEOPLASTIC SKELETAL METASTASES FROM CARCINOMA OF THE BREAST: REPORT OF AN UNUSUAL CASE

Arch Surg. 1925;11(2):219-236. doi:10.1001/archsurg.1925.01120140050004

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Abstract

Metastatic invasion of the skeleton in carcinoma of the breast is of very frequent occurrence. Although many pathologists place its incidence at an average of 20 per cent., some have found its prevalence to be much higher. In Kaufman's series it yielded 53.3 per cent. In Snow's small unselected number of cases, it gave 75 per cent. Observations at the Montefiore Hospital coincide with those of the latter two investigators. During the years 1913-1923, there were admitted to the cancer division of Montefiore Hospital sixty-seven patients with advanced cases of breast carcinoma. Of this number, fifty (74.6 per cent.) showed multiple metastatic lesions in the skeleton, demonstrated either at necropsy or on roentgenologic examination.

This extremely high incidence of skeletal metastases in carcinoma of the breast makes it one of the most important problems, not only to the pathologist and cancer worker but also to the clinician, roentgenologist and radiotherapeutist

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