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Article
August 1925

THE SECRETION ANTECEDENTS AND MITOCHONDRIA IN PATHOLOGIC THYROIDS: A THEORY OF THE MODE OF SECRETION IN THE THYROID GLAND

Author Affiliations

ST. LOUIS
From the laboratories of the department of medicine of the Medical School of Harvard University.

Arch Surg. 1925;11(2):254-303. doi:10.1001/archsurg.1925.01120140085006
Abstract

That increased basal metabolism is associated with increased thyroid activity is well known and requires no comment here. It has, however, been observed that the pathologic picture in adenomas of the thyroid does not always correspond to the clinical state.1 In exophthalmic goiter there is quite general agreement as to the pathologic changes present in the various stages of the disease.2 The pathology of simple goiter and of fetal and simple adenomas is quite clear.3

It has long been known that certain nonexophthalmic goiters were accompanied by toxic symptoms. Plummer,4 in reviewing the cases at the Mayo Clinic, found that 23 per cent, of the nonexophthalmic goiters were toxic, and presented either one or the other of two definite clinical pictures: one type resembling exophthalmic goiter, and the other having a predominance of cardiac symptoms. Wilson5 reviewed the glands of the cases studied by Plummer,

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