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November 1925

EXPERIMENTAL HYDRONEPHROSIS: THE EFFECT OF CHANGES IN BLOOD PRESSURE AND IN BLOOD FLOW ON ITS RATE OF DEVELOPMENT II. Partial Obstruction of the Renal Artery: Diminished Blood Flow; Diminished Intrarenal Pressure and Oliguria

Author Affiliations

From the Department of Urology and Hooper Foundation of Medical Research of the University of California Medical School.

Arch Surg. 1925;11(5):649-659. doi:10.1001/archsurg.1925.01120170002001

The effects on the rate of development of hydronephrosis of an increase in blood flow and blood pressure, brought about by unilateral splanchnotomy have been described1 with the conclusion that the rate of urinary secretion as affected by this procedure influences very little, if at all, its ordinary rate of development with complete ureteral obstruction. Partial compression of one renal artery will produce the opposite effect—permanent unilateral oliguria. When the renal artery is partially compressed, there is a diminished blood flow and a diminished intrarenal blood pressure which together reduce the amount of urine secreted and lower the maximal back pressure with ureteral obstruction. What interference will this change have on the rate of development of hydronephrosis?

Herman,2 as early as 1862, studied the effect of this procedure on urine secretion. He employed a screw clamp by means of which he was able to vary the compression, and

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