In previous articles,1 we have called attention to certain quite constant and characteristic chemical changes taking place in the blood of the dog after experimental high intestinal obstruction. Very quickly after the obstruction is made, the chlorids of the blood begin to fall with a coincident increase in the carbon dioxid combining power of the plasma. After the store of body chlorids is depleted below a certain level, usually after a loss of about one fourth of the blood chlorids, the rise in nonprotein nitrogen previously reported by other observers2 begins.
We have suggested that the behavior of the body chlorids is in some way related to the toxic body or bodies responsible for the characteristic toxemia. It seems very possible that the sodium chlorid, probably as hydrochloric acid, converts the toxic into nontoxic bodies. Until all the available chlorids are lost, the action of the toxic bodies
HADEN RL, ORR TG. OBSTRUCTION OF THE JEJUNUM: THE EFFECT OF SODIUM CHLORID ON THE CHEMICAL CHANGES IN THE BLOOD OF THE DOG. Arch Surg. 1925;11(6):859–882. doi:10.1001/archsurg.1925.01120180052003
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