Overgrowth of the long bones resulting in asymmetry is an old observation. Since the roentgen ray has come into general use there have been a greater number of case reports with more accurate observations than formerly. The roentgen ray has been the means, furthermore, of conducting experimentation in an effort to explain the etiologic factors.
The purpose of this article is to describe three cases of overgrowth of the lower extremity, with a distinctly different etiologic factor in each case. All represent an involvement of the tibia in children between the ages of 12 and 14 years.
FACTORS THAT INFLUENCE THE GROWTH OF NORMAL BONE
Normal growth of bone varies with the physiologic demand of the organism for it. Nature seems to provide some mechanism whereby a constant symmetrical progression takes place. Osteoblastic cells located on the proximal portion of the epiphysial line have the quality of proliferation in a
HARBIN M. OVERGROWTH OF THE LONG BONES OF THE LOWER EXTREMITY: REPORT OF THREE CASES. Arch Surg. 1927;14(1):142–149. doi:10.1001/archsurg.1927.01130130146006
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