The group of cases considered here has some unusual features which aroused our interest and led us to make this study of the mediastinum. Frequently the roentgenograms of patients who enter the clinic present shadows that give rise to various interpretations. In general, these roentgenograms show a widening of the normal central or mediastinal shadow. We realized that mediastinal disease was never diagnosed by roentgen-ray observation until this widening had made its appearance; in other words, until the disease had extended beyond the limits of what is usually understood as the mediastinum. The problem that has interested us most has been to determine whether the spread of mediastinal disease follows definite anatomic paths, and to endeavor to discover these paths.
A knowledge of the development of this region is important, and its embryology explains many of its peculiarities and the close relationship in the adult between what at first
LAMBERT AVS, BERRY FB. THE MEDIASTINUM: PATHS OF EXTENSION OF INFECTION FROM FOCUS IN MEDIASTINUM. Arch Surg. 1927;14(1):261–284. doi:10.1001/archsurg.1927.01130130265016
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