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Article
February 1928

EXPERIMENTAL CHRONIC DUODENAL OBSTRUCTION: CHANGES IN THE BLOOD AND OTHER PATHOLOGIC CHANGES

Author Affiliations

NEW YORK
From the Department of Pathology, College of Physicians and Surgeons, Columbia University.

Arch Surg. 1928;16(2):593-605. doi:10.1001/archsurg.1928.01140020144008
Abstract

Our primary object in the experimental production of chronic stenosis of the duodenum was to determine whether there was any relationship between intestinal stasis and alterations in the blood. Clinically, Löwenberg1 and Olivet2 found an increase in the bacterial content of the duodenum in cases of pernicious anemia. Experimentally, Seyderhelm3 claimed to have produced a pernicious anemialike picture in dogs with chronic obstructions of the small intestine. Brown and his co-workers4 reported the occurrence of "toxic nephritis" in a series of cases of chronic duodenal obstruction. Functional studies of the kidneys indicated renal insufficiency. Chemical examination of the blood revealed an increase in the urea nitrogen and creatinine, a high carbon dioxide carrying capacity and a low chloride content.

In previous papers,5 a new technic for producing chronic stenosis of the duodenum was described. The duodenum was chosen as the site of the obstruction because,

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