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Article
April 1928

THE HEALING OF FRACTURES: AN EXPERIMENTAL STUDY

Author Affiliations

SAN FRANCISCO
From the Laboratory of Surgical Research, Stanford University.

Arch Surg. 1928;16(4):942-950. doi:10.1001/archsurg.1928.01140040137008
Abstract

Some years ago I published the results of an experimental study on the healing of fractures in cats.1 Three sets of experiments were performed: simple fractures, incision of the periosteum with instrumental division of the bone, and circular division of the periosteum with instrumental division of the bone. As a result of this work, I came to the following conclusions:

1. When the periosteum is intact, bony union is to be expected.

2. When the periosteum is completely divided, bony union is not to be expected.

3. When the periosteum is slit, bony union may or may not take place.

After an ordinary fracture, hemorrhage takes place from the marrow canal under the periosteum. The periosteum is stripped up from the cortex by this hemorrhage and by the fracture itself. Then come the deposition of fibrin, the formation of granulation tissue and the formation of cartilage and fibrocartilage in

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