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November 1928


Author Affiliations

Jacob Randolph Fellow in Research Surgery PHILADELPHIA
From the Laboratory of Surgical Research and the William Pepper Laboratory, University of Pennsylvania.

Arch Surg. 1928;17(5):813-828. doi:10.1001/archsurg.1928.01140110100003

In 1926, one of us (I. S. R.) with Jonas1 studied the serum calcium and inorganic phosphorus in a series of patients with fractures at diversified sites. From this study we were doubtful as to whether the serum calcium and inorganic phosphorus content in clinical cases could be used as a prognostic index for union or nonunion in the majority of instances.

In 1924, Shipley2 investigated conditions under which calcification occurred in vitro. He found that in slabs of completely rachitic bones, incubated in normal serum, calcification occurred promptly, whereas sections of the same bone in rachitic serum failed to calcify. In 1926, Shipley, Kramer and Howland3 repeated and confirmed Shipley's results, and showed, also, that calcification occurred promptly in slabs of rachitic bone incubated in solutions of inorganic calcium and phosphorus in concentrations similar to those of normal serum. It was their opinion that failure to