From 1916 to 1927, 3,389 patients were operated on in the Lahey Clinic for diseases of the thyroid gland. Of this number, sixty-seven had malignant disease of the thyroid, an incidence of 1.68 per cent. In fifty-four of these sixty-seven cases, the condition was proved to be malignant by the microscopic study of the sections removed, and the remaining thirteen cases were diagnosed as hopeless and inoperable malignant disease by clinical methods alone. A similar incidence of malignant disease of the thyroid was reported by Graham, who said that slightly less than 2 per cent of the thyroids examined in the Lakeside Hospital Laboratory showed malignant disease. Craven stated that from 1 to 5 per cent of all thyroids operated on show a malignant condition, according to the reports of various observers. Portmann in the Cleveland Clinic reported an incidence of 1.6 per cent of malignant disease in persons with
CLUTE HM, SMITH LW. CANCER OF THE THYROID GLAND. Arch Surg. 1929;18(1_PART_I):1–20. doi:10.1001/archsurg.1929.04420010002001
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