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April 1929


Author Affiliations

From the Laboratory for Surgical Research of Harvard Medical School, the Surgical Clinic of the Peter Bent Brigham Hospital, the Laboratory of Experimental Surgery of the University of Rochester School of Medicine and Dentistry, the Surgical Clinic of the Massachusetts Homeopathic Hospital and the Evans Memorial for Clinical Research and Preventive Medicine.

Arch Surg. 1929;18(4):1783-1802. doi:10.1001/archsurg.1929.01140130883058

Knowledge of the physiology of the gallbladder has taken great strides during recent years, but there is still much about this apparently simple organ that is baffling. It is known that the gallbladder stores and concentrates bile during the intervals of digestion and expels it into the intestines on demand. But the specific stimulus and the mechanism through which the contents of the gallbladder are expelled have not been worked out thoroughly. The mechanism for concentration of bile in the gallbladder through absorption of water seems simple, but other functions of the mucosa through which other materials are absorbed are not understood. Ordinarily during fasting, the gallbladder is distended with concentrated bile which tends to become inspissated if the vesicle fails to empty. During this process, varying amounts of mucus are secreted. Though one may assume that this mucus tends to prevent excessive inspissation or to act as a lubricant