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November 1929


Author Affiliations

From the Department of Pathology, University of California Medical School.

Arch Surg. 1929;19(5):794-807. doi:10.1001/archsurg.1929.01150050025004

It is known that an experimental tumor on transplantation invariably reproduces the same kind of tumor as to cell type. For instance, the Rous sarcoma always produces a fibrosarcoma whether it is injected into muscle, bone, connective tissue or an internal organ, such as the liver. When, therefore, an opportunity came to work with an endothelioma, I seized the chance to observe its behavior when injected into the bonemarrow of chickens. The purpose of such a procedure was several fold. First, it was desired to see to what extent it might produce a tumor resembling the much disputed tumor described by Ewing as an endothelioma of bone. Second, it seemed important to watch the development of tumor of the bone-marrow from its inception, a thing impossible to do in man, since in the latter it usually has advanced considerably before it is discovered. Third, the reaction of the bone itself

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