The cause of death in acute intestinal obstruction has not yet been definitely established. Most investigators are of the opinion that it is the result of absorption of a toxin in the obstructed bowel, which may be formed either in the mucosa of the bowel and absorbed directly1 or in the lumen of the intestine as the result of the action of normal digestive secretions, abnormal or perverted secretions2 or of bacteria3 on the stagnated contents of the obstructed bowel. The absorption of this toxic substance within the intestine is thought to be influenced by the degree of damage to the mucosa from distention,3 and by increased intraviscus pressure.4 It is believed by some that the toxic element can be isolated, and that it is a split protein product, which, when injected into normal animals, produces a severe toxemia and death.5 On the other
JENKINS HP. EXPERIMENTAL ILEUS: I. HIGH OBSTRUCTION WITH THE BILIARY, PANCREATIC AND DUODENAL SECRETIONS SHORT-CIRCUITED BELOW THE OBSTRUCTED POINT. Arch Surg. 1929;19(6):1072–1085. doi:10.1001/archsurg.1929.01150060134006
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